Deaf gerbils ‘hear again’ after stem cell cure
By James Gallagher Health and science reporter, BBC News
UK researchers say they have taken a huge step forward in treating
deafness after stem cells were used to restore hearing in animals for
the first time.
Hearing partially improved when nerves in the ear, which pass sounds
into the brain, were rebuilt in gerbils – a UK study in the journal
Nature reports.
Getting the same improvement in people would be a shift from being
unable to hear traffic to hearing a conversation.
However, treating humans is still a distant prospect.
If you want to listen to the radio or have a chat with a friend your
ear has to convert sound waves in the air into electrical signals which
the brain will understand.
This happens deep inside the inner ear where vibrations move tiny hairs
and this movement creates an electrical signal.
However, in about one in 10 people with profound hearing loss, nerve
cells which should pick up the signal are damaged. It is like dropping
the baton after the first leg of a relay race.
The aim of researchers at the University of Sheffield was to replace
those baton-dropping nerve cells, called spiral ganglion neurons, with
new ones.
hey used stem cells from a human embryo, which are capable of becoming
any other type of cell in the human body from nerve to skin, muscle to
kidney.
A chemical soup was added to the stem cells that converted them into
cells similar to the spiral ganglion neurons. These were then
delicately injected into the inner ears of 18 deaf gerbils.
Over 10 weeks the gerbils’ hearing improved. On average 45% of their
hearing range was restored by the end of the study.
Dr Marcelo Rivolta said: “It would mean going from being so deaf that
you wouldn’t be able to hear a lorry or truck in the street to the
point where you would be able to hear a conversation.
“It is not a complete cure, they will not be able to hear a whisper,
but they would certainly be able to maintain a conversation in a room.”
About a third of the gerbils responded really well to treatment with
some regaining up to 90% of their hearing, while just under a third
barely responded at all.
Gerbils were used as they are able to hear a similar range of sounds to
people, unlike mice which hear higher-pitched sounds.
The researchers detected the improvement in hearing by measuring
brainwaves. The gerbils were also tested for only 10 weeks. If this
became a treatment in humans then the effect would need to be shown
over a much longer term.
There are also questions around the safety and ethics of stem cell
treatments which would need to be addressed.
‘Tremendously encouraging’
Prof Dave Moore, the director of the Medical Research Council’s
Institute of Hearing Research in Nottingham, told the BBC: “It is a big
moment, it really is a major development.”
However, he cautioned that there will still be difficulties repeating
the feat in people.
“The biggest issue is actually getting into the part of the inner ear
where they’ll do some good. It’s extremely tiny and very difficult to
get to and that will be a really formidable undertaking,” he said.
Dr Ralph Holme, head of biomedical research for the charity Action on
Hearing Loss, said: “The research is tremendously encouraging and gives
us real hope that it will be possible to fix the actual cause of some
types of hearing loss in the future.
“For the millions of people for whom hearing loss is eroding their
quality of life, this can’t come soon enough.”
Analysis: A hairy problem
While there is excitement at the prospect of using stem cells to
restore nerves in the ear this exact technique will not help the vast,
vast majority of people with hearing loss.
Most hearing problems are caused by damage to the tiny delicate hairs
which convert mechanical vibrations into electricity.
This research group have also converted embryonic stem cells into the
early versions of the hair cells.
However, injecting them into the ear to restore hearing will be no easy
task.
The hairs cells all need to be in the exact place and pointing in
exactly the right direction.
Prof Dave Moore said using stem cells to repair the hairs was “almost
an impossible task” and that the far-fetched concept of growing and
transplanting a replacement ear seemed more likely.
SOURCE: